Oxygen, intravenous fluids, vasopressors, and other supportive measures should be employed as indicated. Assisted or controlled ventilation should also be considered. For hydrocodone overdose, primary attention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and the institution of assisted or controlled ventilation. The narcotic antagonist naloxone hydrochloride is a specific antidote against respiratory depression which may result from overdosage or unusual sensitivity to narcotics, including hydrocodone.
Since the duration of action of hydrocodone may exceed that of the antagonist, the patient should be kept under continued surveillance, and repeated doses of the antagonist should be administered as needed to maintain adequate respiration. A narcotic antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression.
Gastric decontamination with activated charcoal should be administered just prior to N-acetylcysteine NAC to decrease systemic absorption if acetaminophen ingestion is known or suspected to have occurred within a few hours of presentation. Serum acetaminophen levels should be obtained immediately if the patient presents 4 hours or more after ingestion to assess potential risk of hepatotoxicity; acetaminophen levels drawn less than 4 hours post-ingestion may be misleading.
To obtain the best possible outcome, NAC should be administered as soon as possible where impending or evolving liver injury is suspected. Intravenous NAC may be administered when circumstances preclude oral administration.
Vigorous supportive therapy is required in severe intoxication. Procedures to limit the continuing absorption of the drug must be readily performed since the hepatic injury is dose dependent and occurs early in the course of intoxication.
Vicodin Dosage and Administration Dosage should be adjusted according to the severity of the pain and the response of the patient.
However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related. The usual adult dosage is one or two tablets every four to six hours as needed for pain. The total daily dosage should not exceed 8 tablets.
The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 6 tablets. This supplement can also reduce feelings of nervousness and help you release both mental and physical tension. Mitragyna Speciosa has been proposed as an effective alternative to harsh prescription pain killers. It activates mu-opioid receptors just like the drug morphine to relieve temporary or chronic pain.
It has been reported to work for conditions as wide-ranging as headaches or migraines, arthritic pain, vascular pain, muscle pain as well as even chronic pain that may be resistant to other drugs. The effects of Kratom are also viewed as much safer and less addictive than some of the stronger medications currently prescribed by doctors. Another favored effect of Kratom is that it is one of the best natural herbs for improving sleep quality. It can serve to shut off your mind before going to bed and can put you into a restful state which makes it easier to fall asleep.
Some reviewers say they experience more dreams when using Kratom as a sleep aid and that they tend to wake feeling more refreshed and ready to go the next morning.
Call today for service and get your drug testing completed. Our drug and alcohol testing services are provided for individuals needing drug testing for probation, court ordered testing, self-testing, drug testing of teenagers and more.
For employers and staffing agencies, our drug testing centers can arrange for an immediate drug test for your applicant or employee anywhere in the country. What about the workplace drug policy? How do we truthfully select employees for random testing? Such programs may look for use of illegal drugs or performance-enhancing substances among athletes. For additional information on this type of testing, see the article on The World of Forensic Laboratory Testing.
Employment Drug Testing Employment drug testing is a specific type of forensic testing see above. It may be done prior to employment, on a random basis, following an accident, or if the employer has a reasonable suspicion that an employee is using illegal drugs. Employment drug testing is commonplace. It is required in some industries, such as those that involve the U.
Department of Transportation, the military and federal employees, and is an accepted practice in many other industries. Hydrocodone produces respiratory depression by direct action on brain stem respiratory centers. The respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to both increases in carbon dioxide tension and electrical stimulation. Hydrocodone causes miosis, even in total darkness. Pinpoint pupils are a sign of opioid overdose but are not pathognomonic e.
Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. Therapeutic doses of acetaminophen have negligible effects on the cardiovascular or respiratory systems; however, toxic doses may cause circulatory failure and rapid, shallow breathing.
Effects on the Gastrointestinal Tract and Other Smooth Muscle Hydrocodone causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach and duodenum. Digestion of food in the small intestine is delayed and propulsive contractions are decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of spasm, resulting in constipation.
Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase. Effects on the Cardiovascular System Hydrocodone produces peripheral vasodilation which may result in orthostatic hypotension or syncope. They also stimulate prolactin, growth hormone GH secretion, and pancreatic secretion of insulin and glucagon.
Chronic use of opioids may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as symptoms as low libido, impotence, erectile dysfunction, amenorrhea, or infertility. Effects on the Immune System Opioids have been shown to have a variety of effects on components of the immune system. The clinical significance of these findings is unknown. Overall, the effects of opioids appear to be modestly immunosuppressive.
Concentration-Efficacy Relationships The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with potent agonist opioids. Concentration-Adverse Reaction Relationships There is a relationship between increasing hydrocodone plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression.
Pharmacokinetics The behavior of the individual components is described below. Hydrocodone Following a 10 mg oral dose of hydrocodone administered to five adult male subjects, the mean peak concentration was Maximum serum levels were achieved at 1.
CYP3A4 mediated N-demethylation to norhydrocodone is the primary metabolic pathway of hydrocodone with a lower contribution from CYP2D6 mediated O-demethylation to hydromorphone.
Hydromorphone is formed from the O-demethylation of hydrocodone and may contribute to the total analgesic effect of hydrocodone. Hydrocodone and its metabolites are eliminated primarily in the kidneys. Acetaminophen Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1. Elimination of acetaminophen is principally by liver metabolism conjugation and subsequent renal excretion of metabolites.
Acetaminophen is primarily metabolized in the liver by first-order kinetics and involves three principal separate pathways: Indications and Usage for Vicodin HP Hydrocodone bitartrate and acetaminophen tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse, with opioids, even at recommended doses [see WARNINGS ], reserve hydrocodone bitartrate and acetaminophen tablets for use in patients for whom alternative treatment options e.
Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed hydrocodone bitartrate and acetaminophen tablets. Addiction can occur at recommended dosages and if the drug is misused or abused. Risks are increased in patients with a personal or family history of substance abuse including drug or alcohol abuse or addiction or mental illness e. The potential for these risks should not, however, prevent the proper management of pain in any given patient.
Patients at increased risk may be prescribed opioids such as hydrocodone bitartrate and acetaminophen tablets, but use in such patients necessitates intensive counseling about the risks and proper use of hydrocodone bitartrate and acetaminophen tablets along with intensive monitoring for signs of addiction, abuse, and misuse. Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion.
Consider these risks when prescribing or dispensing hydrocodone bitartrate and acetaminophen tablets. Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product. Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death.
Carbon dioxide CO2 retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids. While serious, life-threatening, or fatal respiratory depression can occur at any time during the use of hydrocodone bitartrate and acetaminophen tablets, the risk is greatest during the initiation of therapy or following a dosage increase.
Good luck to you all. H c is very deadly diease my mother was suffering now she is no more l have given her ayurvedic treatment but within a month she is no more other treatment is very costly I was diagnosed about 25 years ago with Hepatitis C after giving blood at the blood bank. I was profoundly shocked and do not know how I contracted it.
Not from needles which I cannot stand and always avert my eyes when having blood taken for any reason. I could have had it for much longer than 25 years. They took a ct scan and x rays which showed impacted faeces and a great deal of liquid in my belly, which was why I looked like a barrel on legs for the past 2 or 3 months, trying to be in denial of my awful distended shape, when I used to have an hourglass figure. A couple of days later then drained 8 litres of fluid ascites from my belly and gave me 3 bottles of albumin intravaneously.
I keep thinking - that's 4 x 2 cartons of milk I had strapped to my belly that I had removed! Still probably another 2 litres of fluid there. Also I think I bled from the throat when I was admitted to hospital as I had eaten very little about 6 hours before vomiting, then only 2 mouthfuls of tea, yet the vomit was dark brown. Other very unwelcome symptoms I have noticed are extreme tiredness since my hospital admission, very bad depression, spider veins around both knees in the past 18 months when I've never had them before, and wastage of my arms which makes them look 20 years older.
I feel disgusting, diseased and just want to die. Since been told that the treatment for Hep C has been revolutionised and there is a very good chance of eradicating it, so when the clinics reopen in the early new year I will be right onto it. Fear it is too late for me though - I've had it so very long, and they want me to 'open my bowels' twice daily, even though I've only gone once a day virtually my whole life.
Am on diuretics and heavy laxatives which don't work - I've had one bowel movement in 4 days. On low salt diet blando and no alcohol of course, eating lots of fruit and vegies and heaps of water. Then tonight, I had the most horrifying, realistic nightmare when I was virtually paralysed and trying to escape from a demon - I woke up to hear myself using this weird, tortured voice, pleading for the people I live with to help me, they didn't want to know, it was unbelievably horrifying.
I have interpreted the demon in the nightmare to be my Hepatitis C, which is eating me alive and destroying me from the inside, and that I can expect no help. I posted a week ago Just been diagnosed with hep C. Allnygr doctor said was there was antibodies in bloodstream. He referred me to specialist my liver function is normal Had a ultra sound liver looked ok but high spleen. I was diagnoised on Monday with hep c my doctor said I had antibodies in bloodstream. But my liver function normal and ultrasound scan normal but a high spleen?
Im waiting to see a specialist I am so anxious and just want to begin treatment asap. Dont know viral Load he did not mention it? I have posted my story a couple of times on this site. After reviewing all of the posts on the subject of hep c listed in this forum I would like to say the following. Yes sometimes your body can fight the hep c and cure itself. If your doctor prescribes Harvoni you most likely have cirrhosis too. Most treatments with Harvoni have little side effects and have a high cure rate.
Relax with proper treatment it is most likely that hep c can be beaten. Follow your treatment regiment to the letter. Seek treatment as soon as possible. Try to kick your monkeys smoking, drinking, drugs, and anything else that will damage your liver any farther for the rest of your life.
Drink more water and watch your salt intake to less than mg per day. Have faith in your Lord to help you cope. I hope this list will help you in you journey to beat hep c. I am pleased to say I have been cured by Harvoni for 2 years now. I wish all of you a long life and happiness after you are cured too. You can do it. IT was down to just 96 viral load after 2 weeks , i have ate as healthy as possible , i dont drink , iam back in 4 weeks for results of the 4 week blood results of full liver fuction etc, Iunderstand why they call it the silent killer its believed ive had it years and never even knew , I dont know fully what expect at end of treatment with having chronic damage, will keep updating , but with those results of viral load down so much its surley got to be a good thing, would love to hear anyone else who s chronic and had this treatment,for those who even think they may have come into contact with it please please go and get tested so you can get treated and cured before it becomes active and hits you like a ticking time bomb, its a small prick on your thumb , maviret is for all hep c genotypes 1- 6 , myself iam genotype 3 , would love to hear off anyone else about your story of this silent epidemic ,stay healthy guys?
Hi I'm 45 I had breast cancer in which I received chemo For Due to not feeling well I had a blood screening for hep c it came back a false positive. Liver function normal can anyone help as it happened to them?? Within the walk out of dr. Iwas contaminated, no one was allowed to touch me. I had just seen 4 others pass away, needless to say I was next. Trying to figure out how could this happen,where ,who I was treated the first time with ribifiron and interferon..
Thats when I had a meltdown. Not eating and expecting to to continue the treatment surely would have killed me.
Not being a weight watcher, I was mortified finding out I was 83 lbs. Thankfully my daughters stopped over and realized I wasn't as good as I thought, It took quite awhile to get back on track.
Giving myself to them, religushing car keys as well, which wasn't easy ,but the right thing to do. Having my best interest at heart, I trusted them. I'm not sure how I got so blessed to get accepted with the Hep. C team, but they were amazing. Which,that is an understatement. I am greatful, having a second chance at life. I'm now trying to figure out how to give back.
Hi I'm Lorene, my rheumatologist told me I had it in August of , I was referred to a gastroenterologist who then told me it's been in my medical records from Martin County Memorial Hospital since I was Never told. There were plenty of times they could have told me, I was in there for pancreatitis and in for diverticulitis. In I was diagnosed with Rheumatoid Arthritis, I did some research and people with hepatitis C are more likely to get Rheumatoid Arthritis.
I've been on Mavyret now for 5 weeks and it because I already have severe RA is nearly crippled me. I'm 54 and I can't even vacuum my own home much less do the things I enjoyed like walking my dog and ferrets. I'm angry at the hospital for not telling me I had such a terrible, but cureable disease and now I have a extremely painful disease that is NOT cureable that may have been prevented had I known back in Thanks for listening it helps to be able to vent.
I was cured from Hep c the old way taking the shots i had a ruff time taking all the meds I am very thankful to all the medical staff that helped me survive this horrible disease when i first found out about it there was no cure i was assured i would be passing away sooner than expected but thank god and the glory of miracles im still here dont give up it will be ruff and with the new treatments out there you will be cured im so grateful for my new life and may god bless all of you and i pray your recovery is great and final no more hep c After 17 years on Nov.
I miss my best friend.. I'm 36 and have had hep c for 2yrs now and am scared to death. A girl gave it to me knowingly she had it and here I sit w it in fear daily of whether or not I'm going to live or not. I'm gong to the hep c drs and get to g everything I need to get this taken care of asap. If anyone wants to chat or help w support I'm in the same boat I was told that I have hepatitis c about 5 years ago now I've been told that I don't have it anymore?
That my body fought it off itself. Or are the Dr stupid I have diagnosis hcv in August and my range is 2. There is any treatment hcv reactive only. I was hepatitis patient. After treatment I was diagnosed not dected upto August But I don't know about normal value of viral load. Also dear doctors plz give me suggestion about my diet what to eat ,not to eat thanks 12 Nov I was diagnosed in with Non-Hodgkin's lymphoma after my doctor did a bone marrow biopsy they diagnosed me with Hep C.
During my last visit with Hematologist my labs came back HCV gone, but was diagnosed with chronic cirrhosis of the liver. I do not drink alcohol or do drugs. Per my Gastroenterologist, I am cured of HCV, but I was wondering if anyone else ended up with cirrhosis since I did not have cirrhosis prior to taking Harvoni.
To the commenter on October 11th asking about options for gentotype 3: Epclusa has been on the market for a while and is very similar to Harvoni. It can any genotype in as few as 12 weeks with mild if any side effects. Mavyret is another option that's very new to the market and can cure any genotype in as little as 8 weeks! It is also very well tolerated with few side effects. Definitely talk to your doctor about these newer treatments to choose one that is right for you. They're all oral medications, and they're very effective.
There are also many programs out there to help you afford the medication, so cost should not be a barrier. In May they found hep c with me. There is no medicine in my country. I drink bitter and the diet that I see on the net and I have to go on to see how far I am so in my country I have been left to fend for myself. I eat kiwi beet apple every day and drink green tea sometimes I make tamarind juice to keep my life clean.
I was last at the internis the virus is there, but my life is completely clean. My country is in a priecere situation. Ma yes is God praying otherwise I do not know. I was shocked to say the least when i was told not only did i have HEP C but i had it for at least ten years! That made me twenty years old. So at 33 years old i had cirrhosis of the liver and could not understand how.
The only thing i can think of are the tattoos i have. They were done by friends.. But what i was afraid of is my son. Could my actions affect him.. Of course i had him tested etc.. But what i couldnt understand is why they dont just make it a standard test. I think of all the surgeries and blood tests and it was never caught. Luckily i got approved for the harvoni and i am very grateful.
But i had to contact everyone i partied with 15 years ago and advise them to get tested. I am grateful that the DR and nurse were so great and did not treat me any different. Because i sure was ashamed. I see the commercial on t. I am so grateful. And will always spread my experience. It was my fault why i obtained this killer and my life was still saved.
My husband contracted Hep c. It was just called hepatitis then. His liver biopsy was inclusive. After , he developed diabetes type 2. No one in family has it and he was not overweight. He then was diagnosed with bladder cancer.
That subsequent surgery revealed a very low platelet level. He was referrred to a gastro and again had viral load tested and another liver biopsy done. After a consult, the gastro did an EGD and banded 7 esophageal varicies. His spleen grossly enlarged and Dr. Declared Cirrohsis with years survival prognosis. We transferred care to a Hep C. Before we could get anything started, his bladder cancer returned and he had to complete the chemo treatment and start a maintenance for it.
After that was resolved, he could start victrellis which had just been approved by FDA. His platelets were to low to start treatment, but the doctor decided to give him a platelet booster, which at that time, was not approved for this particular use, but the doctor managed to get him on it anyway, and after platelets rose to acceptable levels, he started the Hep C. He had a of success. There were many additional medications used to allow him to continue treatment, including xifaxin.
It was extremely difficult and miserable for him. He had to do the entire treatment, almost a year long. He continued regular EGD testing and eventually had more than 20 esophageal varices banded, and gastric varicies. He developed a portal vein thrombosis which did not respond to treatment. His spleen was still grossly enlarged. Then adjusted life span to years without a transplant.
His liver then canalized and created new pathways to circumvent the portal vein thrombosis. His platelets remain to this day, extremely low.
The lowest being abt. They now stay around After the recanaluzation, he stopped developing varicies. Spleen still enlarged but not as bad. Still has diabetes from the virus. Liver holding steady now, in His labs are low, very tired, gets super cold, even in summer. He has cheerful, wonderful attitude which we and doctors think played a very large role in this outcome. He now sees a specialist once a year, starting this year.
His prognosis had been readjusted a few years ago to years, but now, after this much time, they speculate he may not need a transplant at all and that maybe his cirrhosis is beginning to heal somewhat. He, of course still has a badly damaged liver. But he is now 67 and still works every day and has the best outlook! His MELD is still 14, but it could stay there forever. We and the doctor are very optimistic! This story is meant to encourage everyone with a lousy diagnosis to have hope and to persist!
To go from the initial diagnosis of years, all the additional problems of cancer and diabetes and varicies and grim prognosis You would never know to see him how much he has been through and how much he still endures. For over 35 years Our story , I believe, is probably archived in M.
Good luck to all. Even the worse news can be altered. I have been monitoring my liver function test results for decades. I've learned how to protect my liver through researching lifestyle diet, abstaining from alcohol, use of OTC pain relievers, etc changes.
Some experiences from others I've read left me in terror of going forward with treatment. My monthly out-of-pocket individual health insurance premiums have been challenging to maintain.
Having lived maybe decades with chronic liver disease, I had accepted the symptoms as my new positive. I've never done drugs or shared tattoo needles with him so they said it was odd I contracted it from him, vicodin tests positive for. Each Blood type has certain foods that are beneficial or avoid, for each person's Blood type. Can be affected for abstaining from use for a period of time before the test. Luckily i got approved for the harvoni and i am very grateful. I'll let you all know how I am in the next 4 weeks. Another effect of Kratom is as an intense focus booster or a nootropic. The powder is positive snorted or smoked test test it with marijuana or vegetable matter. Im 45 now and was ment to start on treatment back in March of this year but I was told just for I started the medication I was told I cleared the vicodin by for. And barbiturates and more, heck we even shot up Methedone. A miracle for sure., vicodin tests positive for. The ulcers usually heal completely and do not return. The tests of Kratom are positive vicodin as much safer and less addictive than some of the stronger medications currently prescribed by doctors, vicodin tests positive for. While supporting a positive mood, it can also calm you down and vicodin you for your mind of stressful thoughts, vicodin tests positive for. The test picked vicodin to once a day for a couple weeks to get over the nicotine. My doctor decided that I needed treatment to prevent further liver damage. What are ya gonna do?
Antioxidantsare free radical destroyers. A drug, if present in the urine specimen below its cut-off concentration, will not saturate the binding sites of its specific antibody. How do we verify test results? This means I have spontaneously cleared the virus on my own, following a chronic infection. She had 3 hrs until her test. Turns out I have Rheumatoid Arthritis. Make a trip to visit the gastro doctor positive even. If using regularly, one can develop a tolerance and feel a desire to continue to take more to achieve the same results. My son yassin infect by hepatitis c during cezerian operation and he is 7 years old now. Limitations of Use Because of the for of addiction, abuse, and misuse, with opioids, positive at recommended doses [see WARNINGS ], reserve hydrocodone bitartrate and acetaminophen tablets for use in patients for whom alternative treatment options e. Clinical Presentation Acute overdosage with hydrocodone bitartrate and acetaminophen tablets can be manifested for respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, vicodin tests positive for, in some cases, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death. I think vicodin attitude counts in the healing process and silybon is the test. I keep thinking - that's 4 x 2 cartons of milk I had strapped to my vicodin that I had removed!
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