Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Do not use this medicine if you have taken an MAO inhibitor in the past 14 days.
A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
In some people, codeine breaks down rapidly in the liver and reaches higher than normal levels in the body. This can cause dangerously slow breathing and may cause death, especially in a child. Acetaminophen and codeine should not be given to a child younger than 12 years old.
Do not give this medicine to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids. Do not breast-feed while taking acetaminophen and codeine. A narcotic antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Serum acetaminophen levels should be obtained, since levels four or more hours following ingestion help predict acetaminophen toxicity.
Do not await acetaminophen assay results before initiating treatment. Hepatic enzymes should be obtained initially, and repeated at hour intervals. Toxic Doses for adults Acetaminophen: Pharmacokinetics The behavior of the individual components is described below. Codeine Codeine is rapidly absorbed from the gastrointestinal tract.
It is rapidly distributed from the intravascular spaces to the various body tissues, with preferential uptake by parenchymatous organs such as the liver , spleen and kidney. Codeine crosses the blood-brain barrier and is found in fetal tissue and breast milk. The plasma concentration does not correlate with brain concentration or relief of pain ; however, codeine is not bound to plasma proteins and does not accumulate in body tissues.
The plasma half-life is about 2. The remainder of the dose is excreted in the feces. At therapeutic doses, the analgesic effect reaches a peak within 2 hours and persists between 4 and 6 hours. Acetaminophen Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most body tissues. The plasma half-life is 1.
Elimination of acetaminophen is principally by liver metabolism conjugation and subsequent renal excretion of metabolites. Such tasks should be avoided while taking this product. Alcohol and other CNS depressants may produce an additive CNS depression , when taken with this combination product, and should be avoided. Codeine may be habit forming. Patients should take the drug only for as long as it is prescribed, in the amounts prescribed, and no more frequently than prescribed.
Caution patients that some people have a variation in a liver enzyme and change codeine into morphine more rapidly and completely than other people. These people are ultra-rapid metabolizers and are more likely to have higher-than-normal levels of morphine in their blood after taking codeine, which can result in overdose symptoms such as extreme sleepiness, confusion, or shallow breathing. In most cases, it is unknown if someone is an ultra-rapid codeine metabolizer.
Get medical help right away if you take too much acetaminophen overdose , even if you feel well. Daily alcohol use, especially when combined with acetaminophen, may damage your liver.
Before using this medication, women of childbearing age should talk with their doctor s about the risks and benefits. Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy , this medication should be used only when clearly needed. It may slightly increase the risk of birth defects if used during the first two months of pregnancy.
Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby.
Get medical help right away if any of these safe serious side effects can i mix meloxicam and hydrocodone Naloxonea narcotic antagonistcan reverse respiratory depression and codeine associated with opioid overdose. Also, large amounts of acetaminophen may cause liver damage if taken for a dose time. Children younger than 12 years should not use products that contain codeine. At higher doses, codeine has most of the disadvantages of morphine including respiratory depression. Ask your doctor or pharmacist how much acetaminophen is safe to take. Renal tubular necrosis, safe dose of tylenol with codeine, hypoglycemic coma and thrombocytopenia may also occur. Your doctor may adjust tylenol dose as needed. Do not keep outdated medicine or medicine no longer needed, safe dose of tylenol with codeine. Vasopressors and other supportive withs should be employed as indicated. Talk with your doctor or pharmacist about the risks and benefits of this medication. Before using this medication, women of childbearing age should talk with their doctor s about the risks and withs. Codeine or tylenol narcotics may obscure signs on which to judge the diagnosis or clinical course of doses with codeine abdominal conditions. Toxic Doses for adults Acetaminophen: Meticulous attention should be given to maintaining safe pulmonary ventilation. Consequently, the extended use of this product is not recommended.
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