Take as directed Dexamethasone oral tablets are used for long-term treatment. They come with serious risks if you don't take them as prescribed. If you stop taking the drug suddenly or don't take it at all If you don't take the drug at all, your condition won't be controlled.
If you stop taking dexamethasone suddenly, you may have withdrawal side effects. Don't stop taking dexamethasone unless your doctor tells you to do so. If you miss doses or don't take the drug on schedule Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include: If your symptoms are severe, call or go to the nearest emergency room right away. What to do if you miss a dose If you miss a dose, wait and take the next dose as planned. Don't double your dose. This could result in dangerous side effects. How to tell if the drug is working The symptoms of your condition should be reduced.
Important considerations for taking dexamethasone Keep these considerations in mind if your doctor prescribes dexamethasone for you. General Take dexamethasone with food. Taking it with food can reduce stomach upset from the drug. Take this drug at the time s recommended by your doctor. You can cut or crush the tablet. Don't store this medication in moist or damp areas, such as bathrooms.
Cyclosporine Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. Convulsions have been reported with this concurrent use. Thus, results of the DST should be interpreted with caution in these patients. Digitalis Glycosides Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia.
Ephedrine Ephedrine may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and lessened physiologic activity, thus requiring an increase in corticosteroid dosage. Estrogens, Including Oral Contraceptives Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.
Drugs which inhibit CYP 3A4 e. Dexamethasone is a moderate inducer of CYP 3A4. Co-administration with other drugs that are metabolized by CYP 3A4 e. In addition, ketoconazole alone can inhibit adrenal corticosteroid synthesis and may cause adrenal insufficiency during corticosteroid withdrawal.
Nonsteroidal Anti-Inflammatory Agents NSAIDS Concomitant use of aspirin or other nonsteroidal anti-inflammatory agents and corticosteroids increases the risk of gastrointestinal side effects.
Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. The clearance of salicylates may be increased with concurrent use of corticosteroids. Phenytoin In post-marketing experience, there have been reports of both increases and decreases in phenytoin levels with dexamethasone co-administration, leading to alterations in seizure control.
Skin Tests Corticosteroids may suppress reactions to skin tests. Thalidomide Co-administration with thalidomide should be employed cautiously, as toxic epidermal necrolysis has been reported with concomitant use. Vaccines Patients on corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response.
Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines. Increased dosage of rapidly acting corticosteroids is indicated in patients on corticosteroid therapy subjected to any unusual stress before, during, and after the stressful situation. Cardio-Renal Average and large doses of corticosteroids can cause elevation of blood pressure, sodium and water retention , and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses.
Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion. Literature reports suggest an apparent association between use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction ; therefore, therapy with corticosteroids should be used with great caution in these patients. Endocrine Corticosteroids can produce reversible hypothalamic-pituitary adrenal HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment.
Adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. If the patient is receiving steroids already, dosage may have to be increased. Metabolic clearance of corticosteroids is decreased in hypothyroid patients and increased in hyperthyroid patients.
Changes in thyroid status of the patient may necessitate adjustment in dosage. Infections General Patients who are on corticosteroids are more susceptible to infections than are healthy individuals. There may be decreased resistance and inability to localize infection when corticosteroids are used. Infection with any pathogen viral, bacterial, fungal, protozoan or helminthic in any location of the body may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents.
These infections may be mild to severe. W ith increasing doses of corticosteroids, the rate of occurrence of infectious complications increases. Corticosteroids may also mask some signs of current infection. Fungal Infections Corticosteroids may exacerbate systemic fungal infections and therefore should not be used in the presence of such infections unless they are needed to control life-threatening drug reactions.
Special Pathogens Latent disease may be activated or there may be an exacerbation of intercurrent infections due to pathogens, including those caused by Amoeba, Candida, Cryptococcus, Mycobacterium, Nocardia, Pneumocystis, Toxoplasma. It is recommended that latent amebiasis or active amebiasis be ruled out before initiating corticosteroid therapy in any patient who has spent time in the tropics or any patient with unexplained diarrhea. Similarly, corticosteroids should be used with great care in patients with known or suspected Strongyloides threadworm infestation.
In such patients, corticosteroid-induced immunosuppression may lead to Strongyloides hyperinfection and dissemination with widespread larval migration, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia. Corticosteroids should not be used in cerebral malaria. Tuberculosis The use of corticosteroids in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimen.
If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur.
This medication may mask signs of infection or put you at greater risk of developing very serious infections. Report any injuries or signs of infection e. Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication. Do not have immunizations , vaccinations , or skin tests unless specifically directed by your doctor.
Live vaccines may cause serious complications e. Avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. Avoid contact with people who have chickenpox or measles unless you have previously had these diseases e. If you are exposed to one of these infections and you have not previously had it, seek immediate medical attention.
Nursing Mothers Systemically administered corticosteroids appear in human milk and could suppress growth, decadron 1 mg tablet, interfere with endogenous corticosteroid production, or cause other untoward effects. Renal Diseases To induce a diuresis or remission decadron proteinuria in idiopathic nephrotic syndrome or that due to decadron erythematosus. In addition, ketoconazole alone can inhibit adrenal corticosteroid synthesis and may cause adrenal insufficiency during corticosteroid withdrawal. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. If chickenpox develops, treatment with antiviral agents should be considered. Dietary salt restriction and potassium supplementation may be necessary. Gastrointestinal Abdominal distention, elevation in serum liver enzyme levels usually reversible upon discontinuationhepatomegalyincreased tablet, nausea, decadron 1 mg tablet, pancreatitispeptic tablet with possible perforation and hemorrhageperforation of the small and large tablet particularly in patients with inflammatory bowel diseaseulcerative esophagitis. Kaposi's sarcoma has been reported to occur in patients receiving corticosteroid therapy, most often for chronic conditions. Pediatric Use The efficacy and safety of corticosteroids in the pediatric population are based on the well-established course of effect of corticosteroids, which is similar in pediatric and adult populations. Dermatologic Diseases Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, and severe erythema multiforme Stevens-Johnson syndrome. These infections may be mild to severe. Concomitant use of tablet or other nonsteroidal antiinflammatory agents and corticosteroids increases the risk of gastrointestinal side effects. Special Pathogens Latent disease may be activated or there may be an exacerbation of intercurrent infections due to pathogens, including those caused by Amoeba, Candida, Cryptococcus, Mycobacterium, Nocardia, Pneumocystis, decadron 1 mg tablet, Toxoplasma. Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines. Digitalis Glycosides Patients on digitalis glycosides may be at increased risk of arrhythmias due to decadron. With increasing doses of corticosteroids, decadron rate of occurrence of infectious complications increases. Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose.
Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect. If your symptoms are severe, call or go to the nearest emergency room right away. Fluid And Electrolyte Disturbances Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosispotassium tablet, decadron retention, tumor lysis syndrome. These infections may be mild to severe. You may need to show airport staff the pharmacy label for your medication. Corticosteroids may also mask some signs of current infection. Discuss the risks and benefits with your doctor. Gastrointestinal Steroids should be used with caution in active or latent peptic ulcers, diverticulitisfresh intestinal anastomoses, and nonspecific ulcerative colitissince they may increase the risk of a perforation. Other Abnormal fat deposits, decreased resistance to infection, hiccupsincreased or decreased motility and number of spermatozoa, malaisemoon face, weight gain. If exposed to chickenpox, prophylaxis with varicella zoster immune globulin VZIG may be indicated. Cardiovascular Bradycardiacardiac arrest, cardiac arrhythmias, decadron 1 mg tablet, cardiac enlargement, circulatory collapse, congestive heart failurefat embolismhypertensionhypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction see WARNINGSCardio-Renaledema, pulmonary edemasyncopetachycardiathromboembolismthrombophlebitisvasculitis.
© Copyright 2017 Decadron 1 mg tablet - Tablets DECADRON mg also contain FD Tests for Cushing's syndrome Give mg of DECADRON orally at p.m. Blood is drawn for plasma cortisol..