Driving and using machines Some people may feel tired or dizzy when taking Atacand. If this happens to you, do not drive or use any tools or machines. Lactose is a type of sugar. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. How to take Atacand Always take this medicine exactly as your doctor has told you.
Check with your doctor or pharmacist if you are not sure. It is important to keep taking Atacand every day. You can take Atacand with or without food. Swallow the tablet with a drink of water. Try to take the tablet at the same time each day. This will help you to remember to take it. Your doctor may increase this dose to 16 mg once a day and further up to 32 mg once a day depending on blood pressure response. In some patients, such as those with liver problems, kidney problems or those who recently have lost body fluids, e.
Use in children and adolescents with high blood pressure: Whether this difference has clinical relevance is not yet known. Candesartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of candesartan on blood pressure.
Pharmacodynamics Candesartan inhibits the pressor effects of angiotensin II infusion in a dose-dependent manner. Plasma concentrations of angiotensin I and angiotensin II, and plasma renin activity PRA , increased in a dose-dependent manner after single and repeated administration of candesartan cilexetil to healthy subjects, hypertensive , and heart failure patients. ACE activity was not altered in healthy subjects after repeated candesartan cilexetil administration.
The once-daily administration of up to 16 mg of candesartan cilexetil to healthy subjects did not influence plasma aldosterone concentrations, but a decrease in the plasma concentration of aldosterone was observed when 32 mg of candesartan cilexetil was administered to hypertensive patients. In spite of the effect of candesartan cilexetil on aldosterone secretion, very little effect on serum potassium was observed.
Hypertension Adults In multiple-dose studies with hypertensive patients, there were no clinically significant changes in metabolic function, including serum levels of total cholesterol , triglycerides , glucose, or uric acid. In a week study of patients with non-insulin-dependent type 2 diabetes mellitus and hypertension, there was no change in the level of HbA1c. Pharmacokinetics Distribution The volume of distribution of candesartan is 0.
The protein binding is constant at candesartan plasma concentrations well above the range achieved with recommended doses. In rats, it has been demonstrated that candesartan crosses the blood-brain barrier poorly, if at all.
It has also been demonstrated in rats that candesartan passes across the placental barrier and is distributed in the fetus. Metabolism and Excretion Because candesartan is not significantly metabolized by the cytochrome P system and at therapeutic concentrations has no effects on P enzymes, interactions with drugs that inhibit or are metabolized by those enzymes would not be expected.
Total plasma clearance of candesartan is 0. Biliary excretion contributes to the elimination of candesartan. Adults Candesartan cilexetil is rapidly and completely bioactivated by ester hydrolysis during absorption from the gastrointestinal tract to candesartan, a selective AT1 subtype angiotensin II receptor antagonist.
Candesartan is mainly excreted unchanged in urine and feces via bile. It undergoes minor hepatic metabolism by O-deethylation to an inactive metabolite. The elimination half-life of candesartan is approximately 9 hours. After single and repeated administration, the pharmacokinetics of candesartan are linear for oral doses up to 32 mg of candesartan cilexetil.
Candesartan and its inactive metabolite do not accumulate in serum upon repeated once-daily dosing. After tablet ingestion, the peak serum concentration Cmax is reached after 3 to 4 hours. Food with a high fat content does not affect the bioavailability of candesartan after candesartan cilexetil administration. Pediatrics In children 1 to 17 years of age, plasma levels are greater than 10—fold higher at peak approximately 4 hours than 24 hours after a single dose.
The pharmacokinetics Cmax and AUC were not modified by age, sex or body weight. Candesartan cilexetil pharmacokinetics have not been investigated in pediatric patients less than 1 year of age.
From the dose-ranging studies of candesartan cilexetil, there was a dose related increase in plasma candesartan concentrations. The renin-angiotensin system RAS plays a critical role in kidney development.
RAS blockade has been shown to lead to abnormal kidney development in very young mice. Administering drugs that act directly on the renin-angiotensin system RAS can alter normal renal development.
The pharmacokinetics of candesartan were linear in the elderly, and candesartan and its inactive metabolite did not accumulate in the serum of these subjects upon repeated, once-daily administration. There is no difference in the pharmacokinetics of candesartan between male and female subjects. Renal Insufficiency In hypertensive patients with renal insufficiency, serum concentrations of candesartan were elevated. The pharmacokinetics of candesartan in hypertensive patients undergoing hemodialysis are similar to those in hypertensive patients with severe renal impairment.
Stop using this medication and tell your doctor right away if you become pregnant. Candesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking candesartan. It is not known whether candesartan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
This discussion prevents side effects of Candesartan, when you buy Atacand online. How should I take candesartan? Buy Candesartan for intake exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the direction of your prescription label of shopped Atacand from Online Pharmacy.
Your doctor may occasionally change your dose to make sure you get the best results. You may take candesartan with or without food. Your blood pressure will need to be checked often.
Visit your doctor regularly.
Biliary excretion contributes to the elimination of candesartan. The incidence of abnormal renal function e. After single and repeated administration, the pharmacokinetics of candesartan are linear for oral doses up to 32 mg of candesartan cilexetil. These maximally-tolerated doses of candesartan cilexetil provided systemic exposures to candesartan AUCs atacand were, in mice, approximately 7 times and, in rats, more than 70 times the exposure in man at the maximum recommended daily human dose 32 mg. Candesartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. Drugs that buy viagra stores uk tesco directly on the renin-angiotensin system RAS can have effects on the development of immature kidneys. ACE activity was not altered in healthy subjects after repeated candesartan cilexetil administration. Candesartan and its O-deethyl metabolite tested positive for genotoxicity in the in fiyat� Chinese hamster lung CHL chromosomal aberration assay. Pruritusatacand 8 mg fiyat�, rash and urticaria, atacand 8 mg fiyat�. Changes in renal function including acute renal failure can be caused by drugs that inhibit the renin-angiotensin system, atacand 8 mg fiyat�. Candesartan fiyat� cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Monitoring of blood pressure is recommended during dose atacand and periodically thereafter.
Monitor serum potassium fiyat� such patients. Do not use potassium supplements or salt substitutes while you are taking candesartan, unless your doctor has told you to. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Avoid getting up too fast from a sitting or lying position, atacand 8 mg fiyat�, or you may feel dizzy. Candesartan and atacand inactive metabolite do not accumulate in serum atacand repeated once-daily dosing, atacand 8 mg fiyat�. Seek emergency medical atacand or call the Poison Help line at Candesartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. The fiyat� system RAS plays a critical role in kidney development. In rats, it has been demonstrated that candesartan crosses the blood-brain barrier poorly, if at all. Atacand is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause klonopin withdrawal symptoms sore throat harm fiyat� your baby if used after the third month of pregnancy. Discuss treatment options with women planning to become pregnant. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment, atacand 8 mg fiyat�. The pharmacokinetics after candesartan cilexetil administration have not been investigated in patients with severe hepatic impairment. If you have any of these conditions, atacand 8 mg fiyat�, you may need a dose adjustment or special tests to buy Atacand and safely take this medication. The antihypertensive effects of candesartan cilexetil and losartan potassium at their highest recommended doses administered once-daily were compared in two randomized, double-blind trials.
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