All these effects were reversible within 6 weeks of discontinuation of treatment. No drug-related effect on testes or on mating performance has been seen in rats or rabbits. This decrease in fertility in Finasteride-treated rats is secondary to its effect on accessory sex organs prostate and seminal vesicles resulting in failure to form a seminal plug.
The seminal plug is essential for normal fertility in rats but is not relevant in man. There were three double-blind, randomized, placebo-controlled studies of month duration.
The two primary endpoints were hair count and patient self-assessment; the two secondary endpoints were investigator assessment and ratings of photographs. In addition, information was collected regarding sexual function based on a self-administered questionnaire and non-scalp body hair growth.
The three studies were conducted in men with mild to moderate, but not complete, hair loss. Studies in Men with Vertex Baldness Of the men who completed the first 12 months of the two vertex baldness trials, elected to continue in double-blind, placebo-controlled, month extension studies.
There were men receiving Finasteride for both the initial study and first extension periods up to 2 years of treatment and 60 men receiving placebo for the same periods.
The extension studies were continued for 3 additional years, with men on Finasteride and 23 on placebo entering the fifth year of the study. In order to evaluate the effect of discontinuation of therapy, there were 65 men who received Finasteride for the initial 12 months followed by placebo in the first month extension period. Patients were evaluated annually with PSA and digital rectal exams. Biopsies were performed for elevated PSA, an abnormal digital rectal exam , or the end of study.
The incidence of Gleason score prostate cancer was higher in men treated with finasteride 1. Breast Cancer During the 4- to 6-year placebo- and comparator-controlled MTOPS study that enrolled men, there were 4 cases of breast cancer in men treated with finasteride but no cases in men not treated with finasteride.
During the 4-year, placebo-controlled PLESS study that enrolled men, there were 2 cases of breast cancer in placebo-treated men but no cases in men treated with finasteride. During the 7- year placebo-controlled Prostate Cancer Prevention Trial PCPT that enrolled 18, men, there was 1 case of breast cancer in men treated with finasteride, and 1 case of breast cancer in men treated with placebo. The relationship between long-term use of finasteride and male breast neoplasia is currently unknown.
Front half feels thinner, whispier, can feel the scalp more easily. Now for the results of being a week in to 2X doses of 0. Amazing effects a week in- I have stopped losing hair. Previously I would run my hands through the front portion of my head and come up with 4 or 5 loose hairs consistently. Worse was in the shower when shampooing- Often 10 to 15 hairs in my hand at any one time. The hairs were very thin and miniaturized.
Worse still I was starting to get comments from girlfriend, friends, family about. A week into my treatment I can run my hands through the front of my hair and come up with 1 hair if I'm lucky. I am aware that this speed of efficacy is unusual and not typical for the majority of Finasteride users. Most users seem to count on results appearing months into treatment.
I am already maintainig and thickening at the front also unusual as Finasteride is meant to be less effective in the frontal region. My girlfriend of 2 years agrees and thinks my hair looks visibly better and she speaks her mind, had no problem telling me my hair previously looked like shit, was constantly making bald jokes. My endocrine system is clearly very sensitive to this drug. Now for the bad news. The dose approved for BPH — 5mg — was marketed under the name Proscar.
The finasteride dose approved for hair loss was much lower: This formulation was given the brand name Propecia. As far as side effects were concerned, the trials found: Since the initial approval of Propecia, the 1mg dosage has been challenged. This is due, in part, to increased reports of side effects.
Finasteride dose response Even before Propecia and Proscar were approved, there was already strong evidence that DHT inhibition did not vary much in response to finasteride dose.
This study from , for example, tested dosages ranging from 0. Part 1 of the study tested daily doses of 25, 50, and mg for 11 days.
Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme Website: No specific treatment of overdosage with finasteride is recommended. Pharmacological properties Pharmacotherapeutic group: The enzyme converts testosterone into the more potent androgen dihydrotestosterone DHT. The prostate gland and, consequently, also the hyperplasic prostate tissue are dependent on the conversion of testosterone to DHT for their normal function and growth.
Finasteride has no affinity for the androgen receptor. After 3 months, a reduction of approx.
Additional analyses suggest that the increase in the prevalence of high-grade prostate cancer observed in the finasteride group may be explained by a detection bias due to the effect of finasteride on prostate volume. I was doing the same 25 but every 2 weeks. Dosage adjustment in non-dialysed patients with renal impairment is not necessary. Blatant price gouging and it's insulting to the consumer. During the 4-year, placebo-controlled PLESS study that finasteride men, 75 mg finasteride, there were 2 cases finasteride breast cancer in placebo-treated men but no cases in men treated with finasteride. I am the type of guy who can psych myself out of erections easily. No drug-related effect on testes or on mating performance has been seen finasteride rats or rabbits, 75 mg finasteride. Finasteride dose response Even before Propecia and Proscar were approved, there was already strong evidence that DHT inhibition did not vary much in response to finasteride dose. An independent panel rated standardized photographs of the head in a blinded fashion based on increases or decreases in scalp hair using the same 7-point scale as the investigator assessment, 75 mg finasteride. The seminal plug is essential for normal fertility in rats and is not relevant in man, 75 mg finasteride. In the finasteride group, 6. For example, a high dose of finasteride would lead to a significant reduction in serum DHT levels almost immediately. Because the effectiveness of finasteride lies in its ability to reduce Finasteride levels, the incidence of side effects is likely to be directly proportional to the benefits for hair maintenance and regrowth, 75 mg finasteride. I have a nice dick in terms of length and girth and I want to keep it that way.
For example, a high dose of finasteride would lead to a significant reduction in serum DHT levels almost immediately. The hairs were very finasteride and miniaturized. The half-life of a drug is the amount of time it takes for the body to remove half of the dose. A positive correlation between the proliferative changes in the Leydig cells and an increase in serum LH levels 2- to 3-fold above control has been demonstrated in both rodent species treated with high doses of finasteride. Not severe, but not mild either. Normalization or improvement of finasteride seminal quality has been reported after discontinuation of finasteride. Some are physical, 75 mg finasteride, some are psychological. I don't think that's necessary for the moment. And infinasteride was approved by the FDA to treat male pattern hair loss. And with many users reporting negative side effects from Propeciathe same article argued that reducing the dose could potentially reduce the incidence of side effects: Thus, a 20 times smaller dose than that recommended had the same effect on the DHT, 75 mg finasteride. Had a massive wank session last night, so I am inclined more towards thinking my mild ED is psychological. My balding was effecting my quality of life. Physicians should instruct their patients to promptly report any changes in their breasts such as lumps, pain or nipple discharge. Thinning in front half of head, receding hairline. Most users seem to count on results appearing months into treatment. In theory, finasteride doses would be just as effective.
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